A randomized,double-blind oontrolled study on elficaoy of duIoxetine and paroxitine in treatment of co-occurring depresslon and anxlety disorder

Abstract

Objective To control the efficacy of duloxetine and paroxetine in treatment of co-occurring depression and anxiety disorder.Methods 24 patients with a diagnosis of major depressive episode and anxiety disorder(CCMD-3)were randomly assigned to 6 weeks of treatment with duloxetine or paroxetine in double-blind.The efficacy was assessed with HAMD-17、HAMA and CGI-SI at the end of baseline and 1,2,4,6 weeks aftertreatment.Safety was estimated by TESS,laboratory and physical examination.Results After 6 weeks treatment,the result based on the reduction rate of HAMD and HAMA showed duloxetine was comparably effective as paroxetine.The HAMD scores decreased significantly at the end of 1 week after treatment between two groups(p<0.05).The adverse effects were mild.Conclusions Duloxetine has positive effectiveness in co-occurring depression and anxiety disorder. Key words: Depression; Anxiety disorder; Duloxetine; Paroxetine