Abstract
A two stage randomized design is developed for two treatment clinical trials in which response variables are exponential and the observations are censored by using failure censoring and time censoring in the first and second stages respectively. The censoring time for the second stage is determined from the outcomes of the first stage. An application to testing for the equality of treatment effects is given along with a comparative study with relevant properties.
Highlights
Clinical trials involve a number of treatments and a comparison among the treatments is natural to identify the best treatment
We develop a two stage procedure with failure censoring in the first stage and determine the randomization probability of each second stage subject based on the first stage outcome
We suggest an adaptive time censoring in the second stage, which uses the first stage data in a convenient way to set the censoring time
Summary
Clinical trials involve a number of treatments and a comparison among the treatments is natural to identify the best treatment. The responses in a clinical trial are often time-to-event (e.g. remission) data. Uttam Bandyopadhyay & Rahul Bhattacharya number of human volunteers, a complete experiment results in loss of life. It is not ethically appealing to allow the trial to continue until all the patients respond. Some of the patients do not visit the clinic to register the response. It is neither feasible nor ethical to continue the trial indefinitely, and a curtailment becomes necessary
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
