Abstract
Nephrocalcinosis is an increasingly recognized problem in VLBW infants. We have previously shown that urine in VLBW infants is supersaturated for calcium oxalate and hydroxyapatite. We studied the effect of oral phosphate supplementation on urine lithogenicity using the basic computer program EQUIL 2. 16 VLBW infants were randomized, 8 to receive oral phosphate (Neutraphos 15 mg/kg/d), and 8 to placebo beginning at 10 days of age with stratification on birthweight less than vs. greater than 1000 gms. Gestational age and wt at birth were 26.9±1.8 wks and 882±198 gms respectively(mean±SD). Randomization resulted in similar treatment groups. 8 treated and 6 placebo infants completed the study. Random urine supersaturation (DG) for Ca oxalate, apatite, brushite, uric acid, and Na urate was determined after 56 days of treatment, and are shown below. p-value is from Wilcoxon rank sum test. DG>0 represents supersaturation.
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