Abstract
Introduction: Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viralencephalitis. In animal studies it has shown to inhibit the synthesis and activity of Thromboxane (TXA2)and abate the imbalance between Thromboxane (TXA2) and Prostacyclin (PGI2). As a result, cerebraledema, ischemia and hypoxia could be improved. The aim of this study is to evaluate its effect in thetreatment of viral encephalitis in children. Methodology: Ninety-nine patients with viral encephalitiswere randomly divided into two groups. Ligustrazini Hydrochlorioi (LH) consisting of 51 cases (males30, females 21; age 5 years and nine month ±8 years and 2month) was given LH 4mg/kg per day in 100-300mls of 10% glucose and infused intravenously over a three to four hour period, for 7 days as a courseof treatment. A control groups of 48 cases (males 31, females 17; age 5 years and three month ±4 yearsand three month) received the conventional treatment of Vitamin C(2.0-3.0g), Coenzyme A(100u) andAdenosine Triphosphate (ATP) (40mg) in 100-300 mls of 10% glucose infused intravenously daily for 7days. Results: The total response rate in the LH group and the control group were 94.12% and 68.75%respectively (u=3.271 p<0.05). The average time to improvement was 4.29±1.41 days and 7.31±2.66days respectively. No adverse effect was observed in both groups. Conclusion: We conclude that LH isan effective, safe and well tolerated treatment for children encephalitis.Key words: Cerebral Oedema; Encephalitis; Ligustrazini HydrochlorioiDOI: 10.3126/jnps.v30i2.3451J. Nepal Paediatr. Soc. May-August, 2010 Vol 30(2) 119-122
Highlights
Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viral encephalitis
Chuanxiong has been reported in Chinese literature to be effective in the treatment of acute cerebral infarction and viral encephalitis
Investigations in China have shown that Chuanxiong can inhibit the synthesis and activity of Thromboxane A2 (TXA2) and abate the imbalance between Thromboxane A2 (TXA2) and Prostacyclin (PGI2), relieve cerebral edema, improve cerebral microcirculatory disturbance, enlarge volume of blood flow, inhibit accumulation of erythrocyte and platelet, increase speed of blood flow, expand contracted artery
Summary
Chuanxiong is a herb used in traditional Chinese medicine for the Treatment of viral encephalitis. Investigations in China have shown that Chuanxiong can inhibit the synthesis and activity of Thromboxane A2 (TXA2) and abate the imbalance between Thromboxane A2 (TXA2) and Prostacyclin (PGI2), relieve cerebral edema, improve cerebral microcirculatory disturbance, enlarge volume of blood flow, inhibit accumulation of erythrocyte and platelet, increase speed of blood flow, expand contracted artery. It can promote recovery of degenerated nerve dendritic cell and relieve lesion of ultrastructure of cell through electric microscopy; as a result, cerebral ischemia, edema and hypoxia are improved. The imbalance between TXA2 and PGI2 and demyelination or vasculitis are believed to an important factor in the development of primary or secondary brain
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