Abstract
Background and aims. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP.Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101). Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension). Experimental group received oral 250 mg quercetin hydrate capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5.Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups.According to the Friedman test, there was a significant reduction in pain (P = 0.01) and severity indices (P = 0.00) in the case group. These differences were not observed in the control group(P = 0.26,SI; and P = 0.86, PI). No adverse effect of quercetin was reported.Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.
Highlights
Oral lichen planus (OLP)is a chronic, inflammatory mucocutaneus disorder with an unknown etiology
Most studies have reported a high incidence of the disease and it is reported that about 0.5‒2.5% of the population are affected; the highest incidence of the disease is in the middle aged population with a female predominance.1-8Involvement of the oral mucosa is a common finding and can be the only sign of the disease.[2,6,7]
There were no differences between the two groups in age, gender, erosive size, VAS scores, erosive severity, and previous treatment for lichen planus at the start of treatment (P>0.05)
Summary
Oral lichen planus (OLP)is a chronic, inflammatory mucocutaneus disorder with an unknown etiology. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. This study was conducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups. According to the Friedman test, there was a significant reduction in pain (P = 0.01) and severity indices (P = 0.00) in the case group. These differences were not observed in the control group (P = 0.26, SI; and P = 0.86, PI). No significant therapeutic effect can be considered for quercetin in treatment of OLP.
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