Abstract
Introduction: Type 2 DM is the common form of Diabetes Mellitus. Since there is no complete cure for Type 2 DM, there is need for newer and effective alternatives. Biotin increases insulin secretion in pancreas and glycogen synthesis in liver by increasing the expression of Glucokinase. Objective: To assess the efficacy and tolerability of Biotin as add on therapy to metformin in the management of Type 2 DM in comparison with metformin alone. Methodology:60patients diagnosed with Type 2 DM attending the outpatient Diabetology department of Stanley Medical College and Hospital were (30 patients in each group) were included in the study.. The study duration comprised of 4weeks of treatment period and 2 weeks of follow-up. Assessment of efficacy was done by measuring fasting and post prandial blood glucose values at the end of every week. Results: Both fasting &postprandial blood glucose values were significantly reduced in GROUP II ( Biotin was combined with metformin ) from first week onwards and maintained even till 5th week. Conclusion: Biotin can be safely used as an add on therapy to the existing standard therapy in Type 2 Diabetes Mellitus for better glycemic control without side effects .
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