Abstract
Meeting abstracts Tumor-infiltrating lymphocytes (TILs) play a major role in anti-tumor immune responses, and their presence is correlated with survival in a variety of tumors. These TILs do not reach the pancreatic cancer (PC) cells in significant numbers due to the presence of stroma and a
Highlights
A randomized multicenter Phase Ib/II study to assess the immunological effect of chemoradiation therapy (CRT) in combination with pembrolizumab compared to CRT alone in resectable or borderline resectable pancreatic cancer
Tumor-infiltrating lymphocytes (TILs) play a major role in anti-tumor immune responses, and their presence is correlated with survival in a variety of tumors
There is recent evidence to suggest that CRT can increase the presence of TILs in the pancreatic cancer (PC) microenvironment (PCME), leading to production of interferon-g (IFN-g), which could increase the expression of PD-L1 through a negative feedback loop
Summary
A randomized multicenter Phase Ib/II study to assess the immunological effect of chemoradiation therapy (CRT) in combination with pembrolizumab compared to CRT alone in resectable or borderline resectable pancreatic cancer. Matthew Katz, Bauer W Todd, Gauri Varadhachary, Nicolas Acquavella, Gina Petroni, Timothy Bullock, Craig L Slingluff, Osama Rahma2*. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015
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