Abstract
The possibility of preventing dental caries by taking probiotic bacterium Weissella cibaria (W. cibaria) CMU tablets to alter the pH of the dental plaque in the oral cavity was evaluated. A randomized, double-blind, placebo-controlled trial was performed on adults aged 20 years or older with 20 or more natural teeth. Ninety-two people underwent dental scaling before being randomly assigned to the experimental group (n = 49) or the control group (n = 43). Depending on the group they belonged to, W. cibaria CMU or the placebo was administered to them once daily for 8 weeks before bedtime. Twenty-four subjects were later excluded from the study because the week 8 dosing was not smoothly performed, for a final subject count of 68. The Cariview test was used to evaluate the amount of acid produced by the dental plaque to assess the risk of caries. The results showed that although there was no significant difference between the results of the two groups, the intake of the W. cibaria CMU tablets eliminated the risk of developing dental caries from acid production in the oral flora because the W. cibaria colonizes and lives in the dental plaque and the oral cavity and suppresses acids.
Highlights
The inclusion criteria were adults aged 20 years or older who had 20 or more natural teeth that could comply with the protocol, had no tongue problems, or any other inflammation or neoplasia in the oral cavity, and had a concentration of volatile sulfur compounds (VSCs) of 1.5 ng/10 mL or more by Oral Chroma (FIS Inc., Hyogo, Japan) measurement [22]
Subjects were randomly assigned to the probiotic test group (n = 49) or to the placebo control group (n = 43)
In the past, the Dentocult system was mainly used as a simple method of determining the risk level of caries; but since only specific strains, Streptococcus mutans (S. mutans) and Lactobacilli sp., were cultivated, there was a limitation in reflecting the various flora related to caries activity in the individual’s oral cavity
Summary
Dental plaque, a biofilm composed of various bacterial colonies, exists on the tooth surface [1]. When the homeostasis of the dental plaque is disrupted, the balance of the surrounding environment is disrupted through a change in the composition of the bacterial community. If this condition persists, it leads to pathological conditions that can cause oral diseases such as dental caries and periodontal disease [2]. Pathogenic bacteria that have the potential to cause dental caries to thrive in acidic environments; those that have the potential to cause periodontal disease to flourish in a slightly alkaline environment
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