Abstract
Methods: We included patients with a diagnosis of opiate and benzodiazepine dependence, admitted for detoxification of both substances, in this randomized, double-blind, placebo controlled trial. Patients were randomized to either one of the treatment protocols methadone, diazepam, and carbamazepine (group 1) versus methadone, diazepam, and placebo (group 2). Treatment retention and adverse events (AE) served as primary endpoints.
Highlights
Addiction is regarded as a chronic relapsing brain disease, which requires situation-adapted treatment approaches [1]
Despite frequent co-dependence from opiates and benzodiazepines, studies focusing on polydrug detoxification are scarce [6]
The question was raised whether a concurrent opioid and benzodiazepine detoxification can safely be administered by tapering methadone and diazepam without additional use of carbamazepine
Summary
We included patients with a diagnosis of opiate and benzodiazepine dependence, admitted for detoxification of both substances, in this randomized, double-blind, placebo controlled trial. Patients were randomized to either one of the treatment protocols methadone, diazepam, and carbamazepine (group 1) versus methadone, diazepam, and placebo (group 2). Treatment retention and adverse events (AE) served as primary endpoints
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