Abstract
BackgroundSpinal fusion surgery is associated with significant blood loss, which may result in potential clinical complications, it is necessary to take safe and effective measures to reduce blood loss in surgery. We perform this study to assess the impact of three different hemostatic materials on perioperative blood loss.MethodsWe performed a Randomized Controlled Trial research and recruited patients with lumbar disease into the study between November 2013 and March 2015. All the participants were randomly assigned to 3 groups using a simple equal probability randomization scheme: Group A (Stypro hemostatic sponge), Group B (Collagen hemostatic sponge) and Group C (gelatin sponge). We compared postoperative blood loss between these 3 groups.ResultsIn our study, drainage volume in the first 24 h of patients in Group A and B is significantly smaller, as well as total postoperative volumes of drainage (p < 0.05) during their hospital stay. The drainage volumes in the second 24 h were similar in the 3 groups. We also found that the average drainage Hematocrit (HCT) reduced over time, the average HCT of drainage is 18.04% and 11.72% on the first day and on the second day respectively.ConclusionsHemostatic collagen sponge demonstrated better hemostasis effects than gelatin sponge with lower volume of postoperative drainage volume and blood loss in posterior spinal fusion surgery.Trial registrationThe trial registration number (TRN) of the study is ISRCTN29254316 and date of registration is 25/10/2016. Our trial was registered retrospectively.
Highlights
Spinal fusion surgery is associated with significant blood loss, which may result in potential clinical complications, it is necessary to take safe and effective measures to reduce blood loss in surgery
Spinal fusion surgeries may result in significant blood loss, which is often associated with cardiovascular complications and high rates of allogeneic blood transfusion [1]
The Collagen hemostatic sponge is a product derived from animal original type I collagen from cows
Summary
Spinal fusion surgery is associated with significant blood loss, which may result in potential clinical complications, it is necessary to take safe and effective measures to reduce blood loss in surgery. Spinal fusion surgeries may result in significant blood loss, which is often associated with cardiovascular complications and high rates of allogeneic blood transfusion [1]. It is imperative to take safe and effective measures to reduce blood loss and rates of transfusions after spinal fusion surgeries. The use of hemostatic materials, such as gelatin sponge and other collagen sponges, has led to significant reductions in both intraoperative blood loss and postoperative transfusions [2]. There are many differences between gelatin sponges, which have been in use for several decades, and collagen sponges which have been
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