Abstract
Objectives: To determine whether low-dose aspirin reduces the incidence of pre-eclampsia, reduces perinatal mortality and improves birth weights in pregnant women considered at high risk of developing pre-eclampsia. Method: Two-hundred fifty subjects were recruited from the antenatal clinics at Harare Central Hospital with either a previous history of pregnancy-induced hypertension or pre-existing chronic hypertension and were randomized to receive either 75 mg of aspirin (ASA) or placebo (PLA). Results: Two-hundred thirty subjects (ASA, n=113; PLA, n=117) completed the trial. The odds of developing pre-eclampsia for those on aspirin was 0.72 times those on placebo (95% CI, 0.34–1.52). The mean birth weight was 2774 g for those on aspirin and 2694 g for those on placebo ( P=0.80). No difference was noted in the perinatal deaths (OR=0.38; 95% CI, 0.10–1.20). Conclusion: Prophylactic use of aspirin was not associated with a significant effect on the major pregnancy outcomes assessed in this study.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have