A randomized controlled trial comparing a prepackaged low-residue diet with a restricted diet for colonoscopy preparation: the impact on the results of colonoscopy in adenoma detection.

Abstract

This study aimed to investigate the clinical utility of a prepackaged low-residue diet (PLD) compared with a restricted diet (RD) for colonoscopic bowel preparation. A prospective randomized controlled trial was carried out with patients undergoing colonoscopy. One hundred patients were randomly assigned to PLD and RD groups. In the RD group, the patients received an information sheet containing acceptable low-residue options and instructions from the medical staff. All patients received 10ml sodium picosulphate the day before colonoscopy and 1l of polyethylene glycol with ascorbic acid (PEG-A) on the day of the colonoscopy. If the bowel preparation was not adequate, an additional PEG-A solution was given. The primary outcome was the efficacy of colonic cleansing as rated by the Boston Bowel Preparation Scale (BBPS). The additional amount of PEG-A solution, adenoma detection rate and patient tolerance were assessed as secondary outcomes. The BBPS score in the PLD group was 7.3±1.7 compared with 6.5±1.7 in the RD group. The quality of bowel preparation was significantly better in the PLD group (P<0.05). The mean amount of additional PEG-A solution in the PLD group was smaller than in the RD group (293.8±474.8 vs 444.1±625.0ml), but there was no statistical difference between the two groups. Adenoma detection rates and patient tolerance were similar in the two groups. Prepackaged low-residue diets PLD is superior to RD for bowel preparation for colonoscopy.