A randomized controlled study of the efficacy and safety of dexamethasone in the treatment of pain in patients with emergency trauma

Abstract

Objective To study the efficacy and safety of dexamethasone in the treatment of pain in patients with emergency trauma. Methods From December 2015 to December 2016, two hundred and sixty-four patients were enrolled in the study and randomly divided into the experimental group and the control group, each with 132 cases.In the experimental group, dexamethasone sodium phosphate injection was used as a test drug, and the control group was treated with glucose injection as a placebo.VAS score, overall evaluation, IL-6/ blood glucose and painkillers intake were recorded by physicians at the time of admission (0 h), 6, 12, 24, 48 h after injury.At the same time, wound healing, hospitalization time, fracture healing time and adverse events were recorded. Results The 24 h and 48 h VAS scores in the experimental group were (2.31±0.37) and (1.21±0.13) points, which were significantly lower than those in the control group ((4.12±0.54) points, (3.01±0.51) points). The difference was significant (F (time)=2 917.519, F(Group)=137.507, F (time *group)=83.927, P 0.05). Conclusion The emergency use of dexamethasone can safely and effectively alleviate preoperative pain and expand the indications of dexamethasone.It is beneficial to relieve postoperative analgesia, to reduce the use of morphine and NSAID drugs, and to provide a new way for multimodal analgesia. Key words: Dexamethasone; Pain; Emergency trauma