A randomized control study on anesthetic effects of flurbiprofen axetil combined with propofol on patients with liver cancer receiving microwave ablation.

Xingshi Gu,Yawen Yang,Qiang Yuan,Jian Zhang

doi:10.12669/pjms.36.6.2091

Abstract

Objective:To evaluate the anesthetic effects of flurbiprofen axetil combined with propofol on patients with liver cancer receiving microwave ablation.Methods:Sixty patients (SA grade: I-II) who underwent microwave ablation for liver cancer in our hospital from May 2018 to May 2019 were selected and randomly divided into a study group and a control group (n=30) that were anesthetized through target-controlled infusion of propofol combined with intravenous infusion of flurbiprofen axetil and target-controlled infusion of propofol alone, respectively. The mean arterial pressure (MAP), heart rate (HR), blood oxygen saturation (SpO2), numerical rating scale (NRS) score, adverse reactions and anesthetic effects (induction time, recovery time) of the two groups were compared before anesthesia (T0), at the beginning of puncture (T1), at the beginning of microwave ablation (T2), at the end of microwave ablation (T3) and one hour after surgery (T4).Results:MAP and HR of the study group were higher than those of the control group (P<0.05) at T2. There was no difference in SpO2 between the two groups (P>0.05). The anesthesia induction time and recovery time of the study group were significantly shorter than those of the control group (P<0.05). There was no difference in the NRS score between the two groups at T1 (P>0.05), but the study group had lower scores at T2-T4 (P<0.05). The incidence rate of postoperative adverse reactions was 13.33% in the study group and 46.67% in the control group, with a significant difference (P<0.05).Conclusion:Flurbiprofen axetil in combination with propofol exert evident anesthetic effects on patients with liver cancer receiving microwave ablation. The time of preoperative anesthesia induction and postoperative recovery time can be markedly shortened, and intraoperative vital signs can be maintained stable. This method is thus worthy of clinical promotion.

Highlights

Percutaneous microwave ablation is generally used to treat liver cancer, during which a microwave probe is employed to puncture the vicinity of liver cancer tissue and to promote protein coagulation using highly focused heat in targeting areas, causing irreversible damage to cancer cells and deactivation.[1]
Vital sign changes: mean arterial pressure (MAP) and heart rate (HR) of both groups decreased at T1 and increased, but the SpO2 values of the two groups hardly changed throughout anesthesia
The results showed that the anesthetic drugs used in the two groups had little effect on the vital signs of the patients, but when the patients underwent microwave ablation, they were still affected, and the vital signs changed, while the remaining time was short and the vital signs of the patients in the two groups did not change

Summary

INTRODUCTION

Percutaneous microwave ablation is generally used to treat liver cancer, during which a microwave probe is employed to puncture the vicinity of liver cancer tissue and to promote protein coagulation using highly focused heat in targeting areas, causing irreversible damage to cancer cells and deactivation.[1] due to local high-temperature stimulation, patients tend. Intravenous anesthesia is commonly utilized.[2] Propofol is commonly used for anesthesia induction and maintenance in clinical practice, but it has unstable anesthetic effects.[3] As a nonsteroidal targeting analgesic agent, flurbiprofen axetil is generally used after surgery, but its combinations with other drugs before surgery have seldom been reported.[4] This study was to assess the anesthetic effects of flurbiprofen axetil combined with propofol on patients with liver cancer receiving microwave ablation

METHODS

RESULTS

CONCLUSION