Abstract
A randomized clinical trial of a progestational agent used alone as a contraceptive has been carried out with 2 groups of young women who attended a family planning clinic. The basic plan involved comparisons between ethynodiol diacetate given daily and Ovulen 21, a combined oral contraceptive which contains ethynodiol diacetate as well as the estrogen, mestranol. Blanks were added to the sets of Ovulen 21 capsules so that there was no obvious difference in appearance of the medications. The dosage scheduling was the same for each drug. The most important finding was the increased number of side effects relating to the bleeding pattern in the case of the progestogen used alone.
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