A randomized comparison of thalamic stimulation and lesion on self-paced finger movement in essential tremor

Abstract

Deep brain stimulation (DBS) and ablation (thalamotomy) of the motor thalamus reduce tremor and improve function of the contralateral hand in patients with essential tremor (ET). Neuroimaging and electrophysiological evidence suggest that unlike a focal lesion, high frequency stimulation affects widespread neural networks that include those involved in motor timing. The purpose of this pilot study was to compare the effects of thalamic stimulation and lesion on the timing of simple, self-paced finger movements in patients with ET. Twenty-one subjects with advanced ET were randomized to unilateral thalamotomy or DBS. Nine healthy controls were also enrolled. Index finger tapping was performed on both hands before and 6 months after surgery. Prior to surgery, timing of simple, repetitive index finger taps was abnormal in both TH and DBS subjects on the contralateral hand. After surgery, regularity was improved by both stimulation and thalamotomy with significantly more improvement in the TH group. On the ipsilateral (non-targeted) hand, timing of index finger taps was improved by stimulation. These results suggest that temporal processing is differentially affected by stimulating and lesioning thalamocortical fibers. That timing regularity is improved ipsilateral to the stimulated thalamus provides evidence that DBS influences a widespread neural network involved in timing of simple repetitive movements.