Abstract
To investigate whether in women of high parity induction of labour using a regimen of intravenous oxytocin, increasing incrementally at 45 min intervals, is safer than one increasing at 15 min intervals. University of Benin Teaching Hospital, Department of Obstetrics and Gynaecology, Benin City, Nigeria. Randomised controlled trial. Ninety women of parity 5 or more requiring induction of labour by infusion of oxytocin were randomly allocated to incremental increases at either 45 min intervals (experimental group) or 15 min intervals (control group). Mode of delivery; complications of labour and delivery (uterine rupture, precipitate labour, hyperstimulation, postpartum haemorrhage, perineal tears, puerperal pyrexia); number of days spent in hospital. The 45 min incremental regimen resulted in longer induction-delivery intervals (estimate of difference in population medians 2 h, 95% confidence interval (CI) 1-4 h); less precipitate labour (odds ratio (OR) 0.09, 95% CI 0.03-0.30); less uterine hyperstimulation (OR 0.23, 95% CI 0.09-0.59); and a reduced length of hospital stay (estimate of difference in population medians 3 days, 95% CI 2-5 days). With the 45 min interval regimen there was a reduction in the occurrence of uterine rupture, postpartum haemorrhage, perineal tears and puerperal pyrexia, but these differences did not reach statistical significance. For the induction of labour in women of high parity the infusion rate of oxytocin should be increased every 45 min rather than every 15 min until contractions occur three times in 10 min and this infusion rate of oxytocin is maintained until delivery.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: BJOG: An International Journal of Obstetrics & Gynaecology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.