A randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of rFVIIa as adjunctive therapy for control of bleeding in patients with severe blunt trauma: a re-analysis following the exclusion of early (< 48 hours) deaths

R Rossaint,Y Kluger,S Rizoli,P Iau,K Boffard,B Riou,B Warren

doi:10.1186/cc3400

Abstract

A randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of rFVIIa as adjunctive therapy for control of bleeding in patients with severe blunt trauma: a re-analysis following the exclusion of early (< 48 hours) deaths

Highlights

Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide
This study shows that the inhibition of the intramyocardial expression of tumour necrosis factor (TNF)-α and of its secondary mediator COX-2 related to moderate hypothermia during cardiopulmonary bypass (CPB) is associated with the inhibition of p38 mitogen-activated protein kinase (MAPK)–acute pancreatitis (AP)-1, but not of the NF-κB pathway
Purification, characterization, and analytical mass assignment of inducible nitric oxide synthase (iNOS) from DLD-1-5B2 cells are in progress to provide mass standardization for the iNOS immunoassay

Summary

Introduction

Community-acquired pneumonia remains a common ventilation (MV) were randomized into two groups: one group was condition worldwide. Methods Eighty-one consecutive patients (age 63 ± 16 years, male n = 51, SAPS 2 score 49 ± 11, mechanical ventilation n = 50, vasopressors n = 56, renal failure n = 19, postoperative n = 23) admitted to the ICU during a 3-month period were evaluated. Probiotics administration was suggested to reduce the incidence of infections and the overall morbidity and mortality in surgical patients The aim of this prospective randomized clinical trial was to assess the effects of a combination formula of probiotics and prebiotics (Synbiotic 2000Forte; Medifarm, Sweden) versus prebiotics only (fiber) in critically ill, long-term mechanically ventilated trauma patients. This study examines the acute patient outcomes associated with the evolution of early total care to damage control orthopaedics for multiply injured patients with femoral shaft fractures

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