A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: the UPSIDE study protocol

Julia Spierings,Nicoletta Del Papa,Daan Dierickx,Erik W.a Marijt ,Marc Schmalzing,Reinhard Voll ,Dirk M Wuttge ,Roland Schroers,Vanessa Smith,Madelon C Vonk ,Ellen De Langhe,Ulrich A Walker ,Roger Hesselstrand,Miroslav Mayer ,Per Ljungman,Anna Van Rhenen,Alexandre E Voskuyl ,Karina Gheorghe ,Jeska K De Vries-Bouwstra,Tessa Kerre,Arjan A Van De Loosdrecht ,Joerg Henes,P.m Welsing ,A.c Marijnissen ,Jacob M Van Laar

doi:10.1136/bmjopen-2020-044483

A randomised, open-label trial to assess the optimal treatment strategy in early diffuse cutaneous systemic sclerosis: the UPSIDE study protocol

Julia Spierings, Nicoletta Del Papa + Show 23 more

Open Access

https://doi.org/10.1136/bmjopen-2020-044483

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#Early Diffuse Cutaneous Systemic Sclerosis #Haematopoietic Stem Cell Transplantation + Show 8 more

Abstract
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Abstract

IntroductionSystemic sclerosis (SSc) is a chronic, autoimmune connective tissue disease associated with high morbidity and mortality, especially in diffuse cutaneous SSc (dcSSc). Currently, there are several treatments available in early...

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