Abstract
55 A Randomised Double-blinded Pilot Study to Assess the Effect of Tetrahydrobiopterin and Folic Acid on Macrovascular and Microvascular Dynamic Function using Cardiovascular Magnetic Resonance B. Paul 1,2,∗, D. Wong3,4, A. Mangoni 1, A. Nelson3,4, B. Dundon3,4, S. Willoughby3,4, S. Worthley3,4, M. Worthley3,4 1 Flinders Medical Centre, Australia 2 Prince Charles Hospital, Australia 3 Cardiovascular Research Centre, University of Adelaide, SA, Australia 4 Department of Medicine, Royal Adelaide Hospital, SA, Australia Tetrahydrobiopterin (BH4) is an essential cofactor for the synthesis of endothelial nitric oxide while folic acid prevents BH4 oxidation and scavenges endothelial superoxides. Recent studies have demonstrated a beneficial effect in coronary endothelial function with a single high dose administration of each of these agents. We aimed to study the effects of this combined therapy on predefined macrovascular andmicrovascular endpointsofmyocardial perfusion, aortic distensibility and brachial artery reactivity using magnetic resonance imaging over a 14 day time period. Thirteen successive patients’ with advanced coronary a b a f c d
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