Abstract
A formal total synthesis of (+)-Sch-642305 is described. The synthesis, which commenced from a simple chiral synthon (5 S)-5-(hydroxymethyl)dihydrofuran-2(3 H)-one, employed, as a key step, a radical mediated opening of a chiral epoxy alcohol intermediate with Cp 2Ti(III)Cl following an efficient method developed by us earlier. The resultant intermediate radical was intramolecularly trapped by the electron deficient double bond present in the molecule to give rise to its highly functionalized six-membered carbocyclic ring in stereoselective manner.
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