A radical addition and cyclization relay promoted by Mn(OAc)3⋅2H2O: Synthesis of 1,2-oxaphospholoindoles and mechanistic study

Abstract

Novel and efficient Mn(OAc)3⋅2H2O promoted radical addition-[4 + 1] cyclization relay of 3-indolymethanols and phosphites was disclosed, which afforded 1,2-oxaphospholoindole derivatives in moderate to good yields. Based on the experimental and computational studies, a mechanism involving radical addition and intramolecular cyclization cascade was proposed.