A radiação X não afeta a polpa dentária: um estudo morfológico em ratos

Rafaela Argento,Thiago Oliveira Gamba,Solange Maria De Almeida Boscolo,Grazielle Oliveira Stelter,Gláucia Maria Bovi Ambrosano,Isadora Luana Flores

doi:10.22456/2177-0018.103886

Abstract

Introduction: Radiotherapy is one of the methods used as a treatment for ma-lignant tumors in the head and neck region and it can cause tissue damage in the irradiated areas. In head and neck radiotherapy, teeth are often included within the irradiation area and, consequently, the dental pulp; which receives high doses of radiation. Objective: To evaluate the effects of ionizing radiation on the pulp tissue of rat teeth. Methodology: A double-blind experimental as-say with 35 Albinus Wistar rats divided into seven groups was performed; one control group, three groups irradiated with 15 Gy, and three groups irradiated with 25 Gy. The irradiated groups were submitted to a single dose of radiation and sacrificed 24 hours, 7 days, and 22 days after irradiation, respectively. The samples were evaluated for the morphological presence of inflammatory infil-trate, edema, necrosis, fibrosis, and degeneration of blood vessels. Statistical analysis was performed using the Kruskal-Wallis and Dunn tests with p

Highlights

Radiotherapy is one of the methods used as a treatment for malignant tumors in the head and neck region and it can cause tissue damage in the irradiated areas
Head and neck squamous cell carcinoma (SCC) is one of the most common types of cancer in many parts of the world and it is associated with significant morbidity due to late diagnosis and, the established modality treatment[1]
Due to the lack of a consensus in the literature and contradictory results[2,7,8,9,10,11,12,13,14], we aim to evaluate the effects of ionizing radiation on the pulp tissue of rat teeth using an animal model to verify the direct effects of radiation therapy on the dental pulp morphology exclusively

Summary

Introduction

Radiotherapy is one of the methods used as a treatment for malignant tumors in the head and neck region and it can cause tissue damage in the irradiated areas. Head and neck radiotherapy is associated with a series of acute and chronic toxicities on the tissues of the oral cavity due to the involvement of both the tumor component and the normal anatomical structures of the maxillofacial region in the primary radiation field[3,4,5] In this context, teeth are commonly present in the irradiated area during the treatment of head and neck tumors, and ; the tooth pulp, a loose connective tissue rich in vessels and nerves, receives high doses of radiation[2,3,4,5,6]. The absence of morphological changes in the pulp tissue as a direct result of radiotherapy has been pointed out[7]

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