Abstract
A novel fluorescent probe (cys-pH) based on intramolecular charge transfer (ICT) mechanism for pH detection targeting mitochondria was developed. cys-pH has excellent mitochondrial targeting, a suitable pKa (8.53), a good linear range in the pH range of 6.50–10.00, and a sensitive response to fluctuations in mitochondrial pH. cys-pH has been succeeded in applying to monitor the pH of mitochondria in living cells and the pH detection of water samples in environmental systems. In addition, pH test papers and standard colorimetric cards of cys-pH are prepared. We reasonably explained the double absorption peak of cys-pH UV–vis spectrum in the long wavelength region.
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