Abstract
1. 1. In rats and rabbits injected with (U- 14C) d-lactate labelled dl-lactate the exhalation of 14CO 2 as well as the renal excretion of d-lactate and of labelled metabolites were measured. 2. 2. Dietary adaptation to dl-lactate had little effect on d-lactate metabolism in rats. Only with osmotic diuresis the initial rate of d-lactate excretion was significantly increased after adaptation. 3. 3. The mean elimination of d-lactate by exhaled CO 2, renal d-lactate, renal metabolites, and retention was (μmol C/mmol C given) 855, 29, 37 and 83 in rats vs 440, 29, 29 and 508 in rabbits. 4. 4. Differences between species in d-lactate metabolism were also indicated by the relationship between dose and oxidation rate as well as between dose and renal excretion which suggested different kidney threshold values for d-lactate.
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