Abstract

Acid introduced into the smal intestine of Pavlovpouch dogs inhibits gastric secretion in response to a meal, providing an adequate degree of intestinal acidity is attained. Marked inhibition of secretion occurs if the pH of the intestinal contents is about 2.5 and almost complete depression when the pH is 2.0 or lower. This regulatory effect of intestinal acidity on gastric secretion is not present when the secretion is provoked by histamine. The role of this regulatory mechanism during the secretory period following a meal and the various factors which may be involved are discussed.

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