Abstract
A multiparameter regression analysis utilizing physico-chemical parameters, and commonly known as the Hansch approach has been extended to a set of existing data on olfactive threshold and olfactive stimulatory effectiveness of organic molecules. The compatibility of various parameters has been studied with adequate statistical methods, and we conclude that the lipophilic character (expressed by the octanol/water partition coefficient) of the molecules is an essential parameter related to preliminary non-specific action and transport across the muceous/lipid interphase and the membrane of the olfactive organ. Such an approach allows the refocusing of the problem of the relationship between structure and olfactive properties.
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