Abstract
Evers, Berkowitz and d'Avignon [Nature, 328 (1987) 157; Nature, 341 (1989) 766] have recently determined the steady-state concentration of halothane in rat brain tissue as a function of inspired halothane concentration, using a NMR technique. These investigators reported that the dissolved halothane appears to be distributed in two distinct microenvironments in the brain tissue. The halothane concentration in one of these microenvironments increases linearly with inspired halothane concentration, whereas the concentration in the other microenvironment reaches saturation at about 2.5 vol. % inspired halothane. Moreover, the mobility of the halothane molecules appears to be different in the two microenvironments. It is suggested hereby that these results can be quantified in terms of a “dual-mode” sorption model, which was found to be very successful in describing the solution and transport of a variety of gases and vapors in microheterogeneous polymers.
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