Abstract
During embryonic development, cell specification is tightly regulated in space and time by specific proteins called transcription factors (TFs). To directly interfere with this process, we use a combination of optogenetic light perturbation, real-time imaging of gene expression, and Drosophila genetics to build synthetic spatial and temporal gene activity patterns in living fly embryos. Upon light illumination, TFs translocate from cell nuclei into the cytosolic compartment, which allows control over nuclear TF concentration and thus modulate gene expression.
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