Abstract
In this paper, we proposed a two-state model to quantitatively illustrate the working mechanism of caveolae structure in the regulation of cell membrane stretch. First, we derived the free energy compositions of one caveola in an arbitrary state. This model predicts two local minima for the free energy of one caveola at the completely open and completely closed states at the bottom of a relatively deep curve of free energy at different shape coefficients. The behavior of one caveola is generalized to large number of caveolae in cell membranes using the central limit theory. The dynamic stretching behavior of membrane during a constant-speed tether-pulling experiment is also investigated by making a hypothesis of transition rate between the closed and open states.
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