Abstract
The importance of the adrenal cortex in the regulation of mineral metabolism has been recognized since 1932, and much work has been carried out on the disturbances which result after adrenalectomy and the restoration to normal conditions following therapy with adrenal cortical extracts (Bauman & Kurland 1927, Loeb 1932, see also reviews by Gaunt 1949, Kendal 1948 and Noble 1950). Despite this, no bioassay method based on the direct measurement of this effect, has been developed to date comparable as regards accuracy and sensitivity with the liver glycogen test for the action of substances on carbohydrate metabolism (Venning 1946, Dorfman 1946 and Eggleston 1946). Mineral activity may be assessed by measuring the alteration of sodium and potassium levels either in plasma (Hartman & Spoor 1940, Wirz 1950) or urine (Harrop 1936, Thorn et al. 1938). Both these measurements are subject to wide variation arising from alterations in external factors such as diet,
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