Abstract
BackgroundExisted mathematical models of individual adaptation are mostly reductionist by nature. Researchers usually a priori consider the subject adapted basing only on the fact of continued or prolonged influence of the harmful factor. This paper describes a method that allows assessing the physiological adaptedness to experimental challenges on the basis of holistic approach and quantitative criteria.MethodsThe suggested method comprises simple equations and incorporates into the model an indicator that differentiates functions in regard to their significance for determining physiological adaptedness considered as an outcome of the adaptive process.ResultsThe proposed empirical model affords the possibility of comparing subjects in respect to their resistance to several loads. Physiological parameters were differentiated with regard to their significance for assessing adaptedness. Two examples of animal adaptation to exercise after physical training and plant adaptogen administration are considered.ConclusionThe calculated index of adaptedness is useful in that it replaces wordy descriptions of large tables that reveal alterations in numerous parameters of many subjects under study.
Highlights
Introduction of eleutherosidesUntrained, B Trained, C Untrained, D Trained, E + 1.060 + 2.120 + 2.010 + 1.273Hexokinase − 0.445 −0.048 − 0.500 −0.315 Lactate − 1.163 −0.209 − 0.946 − 0.527
The results of the experiment and their treatment for obtaining the index of adaptedness are presented in Tables 1 and 2
The model may be applied for assessing the functional state and resistance of athletes under different kinds of loads
Summary
Researchers usually a priori consider the subject adapted basing only on the fact of continued or prolonged influence of the harmful factor. This paper describes a method that allows assessing the physiological adaptedness to experimental challenges on the basis of holistic approach and quantitative criteria. Adaptation as an active process of responding to challenges and adaptedness as a result of this process mean achieving a positive outcome, i.e. survival and reproduction, in the face of adversity. Every specialist in the field encounters difficulties in selecting criteria of adaptedness and analysing the results of multifactor experiments, wherein the state of the subject is assessed by a set Melnikov Theoretical Biology and Medical Modelling (2019) 16:15 of numerous parameters. Many researches a priori consider the investigated subject adapted to the given factor only on the basis of its prolonged influence
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