Abstract
The sera expression of human immunoglobulin heavy chain genes and gene complexes was analyzed in different ethnic groups by quantitative determination of Gm allotype antigens. In all populations tested, IgG3 subclass heavy chains of Gm(b+) allotype had greater sera expression than the allele Gm(g). The percentage of IgG3 allotype molecules was higher in Chinese and Easter Islanders than in Caucasians due to higher Gm(b) values. In general, IgG1 allotypes did not show quantitative differences correlated with Gm genotype. A possible exception was the Gmza, g gene complex which had a lower Gm(a) concentration than comparable Chinese sera of different genotype. Certain similarities in the regulation of Gm genes were consistently observed among the populations tested; these included the restricted range of percentage of IgG1 allotype antigens, a gene dosage effect, and differential gene activity of Gmb and Gmg IgG3 Gm genes.
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