Abstract
Silver nanoparticles (SNPs) were synthesized using fungal -amylase. Different sizes of stable SNPs were characterized using Dynamic Light Scattering (DLS) revealed 30 nm, 45 nm, 60 nm and 75 nm, X-ray diffractometer (XRD) showed face centric cubic and High Resolution Transmission Electron Microscopy (HR-TEM) represented spherical in shape. UV-Visible spectroscopy displayed absorption at 412 nm due to Surface Plasmon Resonance (SPR). Fluorescence and Fourier Transform Infra Red (FTIR) spectroscopy has shown the mechanism of structural interaction between SNPs and α-amylase. The thermodynamic parameters viz. free energy (ΔG0), enthalpy (ΔH0) and entropy (ΔS0) suggests that the binding process occurs spontaneously by involving hydrogen bond and van der Waals interactions. Cytotoxic studies on lung cancer cell line (A-549) showed that the synthesized largest size (75 nm) SNPs were more effective than smallest (30 nm).
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