Abstract
An important step in the analysis of fMRI time-series data is to detect, and as much as possible, correct for subject motion during the course of the scanning session. Several public domain algorithms are currently available for motion detection in fMRI. This paper compares the performance of four commonly used programs: AIR 3.08, SPM99, AFNI98, and the pyramid method of Thévenaz, Ruttimann, and Unser (TRU). The comparison is based on the performance of the algorithms in correcting a range of simulated known motions in the presence of various degrees of noise. SPM99 provided the most accurate motion detection amongst the algorithms studied. AFNI98 provided only slightly less accurate results than SPM99, however, it was several times faster than the other programs. This algorithm represents a good compromise between speed and accuracy. AFNI98 was also the most robust program in presence of noise. It yielded reasonable results for very low signal to noise levels. For small initial misalignments, TRU’s performance was similar to SPM99 and AFNI98. However, its accuracy diminished rapidly for larger misalignments. AIR was found to be the least accurate program studied.
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