Abstract

SUMMARY Romifidine (80 μg/kg bwt) was injected iv into 6 healthy mares producing a marked increase in urine production over 90 min (from control value of 0.55 ml/kg/min to mean production of 5.39 ml/kg/min). This increase was accompanied by a relative increase in sodium excretion and a small increase in glucose excretion while the excretion and clearance of creatinine remained constant. Except for hyperglycaemia and a small but significant increase in serum phosphorus concentration, romifidine had little effect on serum and plasma constituents. Possible aetiological factors are discussed.

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