Abstract
A stereological analysis of connective tissue components in phenytoin‐induced gingival overgrowth in children was performed. The volume density (Vv) of the different components was calculated by point counting on semi‐thin sections of interdental papillae from children (n=12) between 8 and 14 years old. This study shows a statistically significant increase in the non‐collagenous matrix Vv and a corresponding decrease in the collagenous matrix Vv in the phenytoin‐enlarged gingiva compared to controls. These results indicate that the PHT‐induced lesion represents a tissue with an altered composition of the connective tissue.
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