Abstract
The stereoselectivity of muscarinic receptors was quantified by the Free-Wilson method. The analysis was performed with the affinity data, published by Gualtieri for certain muscarinic ligands (1,3-oxathiolanes) in three different tissues. The 2 and 3 positions in the 1,3-oxathiolane ring were important to differentiate between the receptors in those tissues. The results also showed that the three chiral centers in the 1,3-oxathiolanes displayed different stereoselective discrimination. The results of the Free-Wilson analysis were compared with those of a previous study on the same compounds obtained by epimeric eudismic analysis. The agreements and differences between the results obtained by these two methods are discussed in depth. Chirality 11:139–143, 1999. © 1999 Wiley-Liss, Inc.
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