Abstract
BackgroundDespite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant strains. Of the estimated 10 million cases globally in 2018, 24% were in Africa, with Nigeria and South Africa making up most of these numbers.Nigeria ranks 6th in the world for TB burden, with an estimated 4.3% multi-drug resistance in new cases. However, the country had one of the lowest case detection rates, estimated at 24% of incident cases in 2018 - well below the WHO STOP TB target of 84%. This rate highlights the need to understand contextual issues influencing tuberculosis management in Nigeria. Our synthesis was aimed at synthesizing qualitative evidence on factors influencing TB care in Nigeria.MethodsA three-stage thematic meta-synthesis of qualitative studies was used to identify barriers and facilitators to tuberculosis case finding and treatment in Nigeria. A search of eleven databases was conducted. The date of publication was limited to 2006 to June 2020. We analyzed articles using a three-stage process, resulting in coding, descriptive subthemes and analytical themes.ResultsOur final synthesis of 10 articles resulted in several categories including community and family involvement, education and knowledge, attitudes and stigma, alternative care options, health system factors (including coverage and human resource), gender, and direct and indirect cost of care. These were grouped into three major themes: individual factors; interpersonal influences; and health system factors.ConclusionCase finding and treatment for TB in Nigeria currently depends more on individual patients presenting voluntarily to the hospital for care, necessitating an understanding of patient behaviors towards TB diagnosis and treatment. Our synthesis has identified several related factors that shape patients’ behavior towards TB management at individual, community and health system levels that can inform future interventions.
Highlights
Despite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant strains
Tuberculosis (TB) remains a global leading cause of death from a single infectious disease, infecting 10 million and killing an estimated 1.2 million people in 2018 [1]. It is caused by the bacillus Mycobacterium tuberculosis, and spread through minute droplets produced through coughing or sneezing [2, 3]
A variety of methods were used in data collection including in-depth interviews, focus group discussions, semi-structured interviews and key informant interviews
Summary
Despite progress in tuberculosis (TB) control globally, TB continues to be a leading cause of death from infectious diseases, claiming 1.2 million lives in 2018; 214,000 of these deaths were due to drug resistant strains. Tuberculosis (TB) remains a global leading cause of death from a single infectious disease, infecting 10 million and killing an estimated 1.2 million people in 2018 [1]. It is caused by the bacillus Mycobacterium tuberculosis, and spread through minute droplets produced through coughing or sneezing [2, 3]. The mixture of high incidence rates of both TB and HIV infections in sub-Saharan Africa adds new levels of complications to diagnosis, emphasizing the need for coordinated and effective control strategies [1, 10]
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