Abstract
We have examined the 17O quadrupole-central-transition (QCT) NMR signal from [17O]nicotinamide (vitamin B3) dissolved in glycerol. Measurements were performed at five magnetic fields ranging from 9.4 to 35.2 T between 243 and 363 K. We found that, in the ultraslow motion regime, cross-correlation between the second-order quadrupole interaction and magnetic shielding anisotropy is an important contributor to the transverse relaxation process for the 17O QCT signal of [17O]nicotinamide. While such a cross-correlation effect has generally been predicted by relaxation theory, we report here the first experimental evidence for this phenomenon in solution-state NMR for quadrupolar nuclei. We have discussed the various factors that determine the ultimate resolution limit in QCT NMR spectroscopy. The present study also highlights the advantages of performing QCT NMR experiments at very high magnetic fields (e.g., 35.2 T).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.