Abstract
We report a 1H-NMR study of the complex formed between naproxen (NAP) and β-cyclodextrin (β-CD) in aqueous medium. Our results confirm that inclusion occurs. Analysis of our data by the continuous variation method shows that the complex has 1 : 1 stoicheiometry. Using Scott's modification of the Benesi-Hildebrand method, we estimate the apparent stability constant of the complex at 298 K in alkaline medium to be 420 M −1. Finally, with the aid of a molecular modelling program, we have determined the most probable structure of the complex. In general our results confirm those of previous studies, although our estimate of the apparent stability constant differs slightly from that reported on the basis of phase solubility results.
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