Abstract
High-resolution NMR spectroscopy has been applied to the study of the interaction of catecholamines, norepinephrine, epinephrine, isoproterenol and their antagonists propranolol and alprenolol with sonicated phospholipids extracted from chicken erythrocyte membranes (CEM). The catecholamine molecules are immobilized by the phospholipids of CEM and the magnitude of the effect seems to depend on the alkyl substitution of their amino group. Upon introduction of alprenolol and propranolol into phospholipid vesicles a broadening of the resonances of theN-methyl alkyl chain and the terminal methyl protons was observed. The results present evidence about the specificity of the interactions of catecholamines with phospholipids from CEM.
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