A protocol of hepatic volume measurement using magnetic resonance imaging in individuals from the Eastern Brazilian Amazon population.

Waldônio Brito Vieira,Apio Ricardo Nazareth Dias,Aline Semblano Carreira Falcão,Luiz Fábio Magno Falcão,Juarez Antônio Simões Quaresma,Robson Tadachi Moraes De Oliveira,Yun-Wen Zheng

doi:10.1371/journal.pone.0229525

Waldônio Brito Vieira, Apio Ricardo Nazareth Dias + Show 5 more

Open Access

https://doi.org/10.1371/journal.pone.0229525

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Abstract

Determination of hepatic volume is an important preoperative procedure and is done through imaging exams or standard liver volume (SLV) formulas developed based on the biotype of each population. In the absence of a specific SLV formula for the Brazilian Eastern Amazon population, the measurement of liver volume is made with reference values from other populations. The aim of study was to compare the hepatic volume in healthy residents from the Brazilian Eastern Amazon population obtained with magnetic resonance imaging (MRI) and recommended SLV formulas validated to other populations. This was a Observational, cross-sectional study. Anthropometric data of 42 healthy individuals aged 18–60 years of both sexes was collected to measure the liver volume through SLV formulas calculations and MRI. MRI shows similarity with the Western European SLV liver volume values and significant differences with the Japan SLV formula, mainly for women, with a moderate-to-weak correlation with the MRI measurements. There was a strong correlation between weight and body surface area in male patients analysed with measurements of the liver volume by the MRI and SLV formulas. The SLV formula based on the Western European population could be used in the absence of a specific formula for individuals living in the Amazon region. The results suggest that liver measurement formulas should take into consideration the sex of individuals, as well as the development of a specific SLV formula for the Eastern Amazon population and the conduction of similar studies in other Brazilian regions.

Highlights

In the Brazilian Eastern Amazon Region, the prevalence of chronic viral hepatopathies in the general population ranges from 1.1 to 2.4% and within blood donors it ranges from 0.8% to 5.9%, the State of Parahaving one of the higher rates in the Region with 2% affected individuals [1]
When comparing the measurements of hepatic volume, independent of sex, using magnetic resonance imaging (MRI) with standard liver volume (SLV) formulas for the Japanese and Western European populations it is possible to notice that the mean values between the MRI method and the SLV Europe formula have similarity when compared to the SLV Japan formula (Fig 2)
The mean values of hepatic volumetry in healthy male individuals using MRI and SLV Japanese and Western European formulas show that the SLV Japan formula is the most distinguishable from the hepatic measurement performed through MRI, as well as the mean of the general hepatic volume, considering the three methods (Fig 3)

Summary

Introduction

In the Brazilian Eastern Amazon Region, the prevalence of chronic viral hepatopathies in the general population ranges from 1.1 to 2.4% and within blood donors it ranges from 0.8% to 5.9%, the State of Parahaving one of the higher rates in the Region with 2% affected individuals [1]. Due to the natural evolution to cirrhosis of chronic viral hepatopathies, imaging methods such as ultrasonography, tomography, and magnetic resonance are frequently employed to define hepatic dimensions, but the diagnosis of hepatomegaly or a reduced liver volume are commonly based only on the measurements of the right and left lobes, which do not always define the liver volume satisfactorily [2]

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