Abstract
BackgroundStudies have indicated that Plantago major L. (P. major) has therapeutic properties, such as anti-inflammatory, antioxidant, antifungal, immunostimulatory, and tissue regeneration. This plant species is assumed to provide potent tissue repair and healing in treatments of skin wound injuries, but the understanding of its effectiveness is still unclear. The systematic review proposed herein aims to assess effectiveness of P. major for wound healing in animal models.MethodsWe will conduct database searches in BVS, PubMed, Scopus, Web of Science, CINAHL, and CABDirect. Reviewers will independently evaluate titles, abstracts, and full-text articles retrieved from databases to identify potentially eligible studies. Relevant articles will be assessed for risk of bias and quality. The database searches will include analysis of wound healing rate through macroscopic evaluation, photo images, or calculation of the wound area retraction until the wound closure. Relevant data will be compiled for the capability and effectiveness of P. major treatments in accelerating wound healing. Random effects meta-analysis models will be employed to compare among groups based on outcome variables from studies reporting sufficient high-quality data.DiscussionResults of this systematic review will be presented in a narrative synthesis form. They will provide a summary and clear understanding of the relevant current questions and evidences directly related to P. major effective tissue repair and healing. Outcomes of this systematic review will contribute with important information that could benefit future research efforts and potential applicability in humans.Systematic review registrationPROSPERO CRD42019121962
Highlights
Studies have indicated that Plantago major L. (P. major) has therapeutic properties, such as antiinflammatory, antioxidant, antifungal, immunostimulatory, and tissue regeneration
P. major has been described to be effective for tissue repair and skin wound healing, but the extent of its effectiveness has not been evaluated
A systematic review on therapeutic effectiveness of this plant species on skin wound healing was not identified in the literature
Summary
Protocol and registration This protocol was registered on PROSPERO (CRD420191 21962). This systematic review will search for primary studies in animal models with cutaneous wounds topically treated with P. major in comparison with the placebo/vehicle control group. Web of Science: (“Wound Healing” OR “Healing, Wound” OR “Healings, Wound” OR “Wound Healings”) (Regeneration OR Regenerations) (“Plantago major” OR “Plantago officinarum”). CABDirect: (Regeneration OR Regenerations) OR (“Wound Healing” OR “Healing, Wound” OR “Healings, Wound” OR “Wound Healings”) AND The following data will be extracted: title, author, year, journal, study type, wound kind, formulation type, treatment time, method, comparison groups, and outcome (Table 1). Criteria for inclusion and exclusion of studies Studies selected for the systematic review must (a) be written in English; (b) use the animal model in rats, mice, and rabbits; (c) include both genders; (d) and focus on acute or chronic cutaneous wound models.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
