Abstract
This study investigated the role of endogenous and exogenous calcitonin gene-related peptide (CGRP) in water immersion stress (WIS)-induced gastric ulcers in rats.WIS produced gastric ulcers which were inversely correlated to the decrease in CGRP-like immunoreactivity observed in the whole thickness of the corpus stomach but not in its mucosal layers.Systemic administration of CGRP (100gmg kg−1s.c.) produced a significant decrease in lesion index of WIS-ulcers and this protection was inhibited by functional ablation of afferent neurons induced by capsaicin pretreatment (100mg kg−1s.c. in two days, a week before the experiments).These findings suggest that sensory endogenous CGRP plays a defensive role in WIS-ulcers.
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