Abstract
F The role of the S100A4 in rat hepatocites was clarified by measuring detailed changes in serum ALT values and intracellular Ca2+ after CCl4 administration. In this study, we further showed that the calcium binding protein S100A4 might be a protein signal involved in the response to protect cells against CCl4 intoxication. S100A4 mRNA expression levels abruptly increased to a high level in normal liver at 1 day after CCl4 administration, and then gradually reduced to the control level by day 3. This change is the opposite to that of intracellular Ca2+.
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