Abstract
IT is recognized that cestrone and progesterone are mutually antagonistic in some of their biological capacities. A fresh example of this antagonism has recently been observed at this Institute. Sixteen male mice, eight of which had been previously castrated, were given ” strone twice a week by cutaneous applications of a 0.01 per cent solution in benzene. On every day following these applications, progesterone was given to some by subcutaneous injections of 0.1 c.c. of a 0.1 per cent solution in sesame oil, to others by the application to the skin of a 0.1 per cent solution in benzene. The mice died or were killed at intervals from the 28th to the 120th day of the experiment.
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