Abstract
Aim: To estimate the levels of serum zinc in children with simple febrile seizures and to compare serum zinc levels between children with febrile seizures and febrile children without seizures. Materials and Methods: A prospective case control study was done on 100 children for a period of one year from June 2018 to January 2019, admitted in Karpaga Vinayaga Institute of Medical Sciences, Padalam, Chennai, who satisfied the inclusion and exclusion criteria. Of these 50 children were diagnosed to have febrile convulsions. The other 50 were febrile children without seizures. Serum zinc levels were measured in all 100 children. Results: Mean Serum zinc levels in children with febrile seizures were 58.4 micrograms/dl and mean serum zinc levels in control group was 94.1 micrograms/dl (p=0.0001). Serum zinc levels were significantly low in children who had febrile seizures of prolonged duration (p=0.0001). Conclusion: These findings revealed that there is correlation between serum zinc and simple febrile seizures. Serum zinc level was significantly lower in children with simple febrile seizures in comparison with febrile children without seizure.
Highlights
Febrile convulsion is one of the most common causes of hospitalization of children in pediatric ward in INDIA
The clinical characteristics of serum zinc levels of cases and controls are shown in table
Its pathogenesis is debatable, studies have revealed that the genetic factors, family background, immunologic disorders, iron deficiency and zinc deficiency may play a significant role in febrile convulsions
Summary
Febrile convulsion is one of the most common causes of hospitalization of children in pediatric ward in INDIA. Febrile convulsions tend to occur in families, the exact mode of inheritance is not known and varies between families. Febrile convulsion susceptibility trait is inherited by autosomal dominant pattern with reduced penetrance. The risk of another child having febrile convulsions is one in five withone affected sibling and one in three if both parents and a previous child had febrile convulsions. The seizure incidence in off spring of individuals with ahistory of febrile convulsion was 10% [2]. The pathogenesis of this condition is still
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
