A PROSPECTIVE OBSERVATIONAL STUDY ON ADVERSE DRUG REACTIONS OF ANTIBIOTICS IN A TERTIARY CARE HOSPITAL

Abstract

The aim of the present study was to detect and analyze adverse drug reactions of antibiotics in a tertiary care hospital. This was a prospective observational study carried out in the Department of General Medicine (Osmania General Hospital) over a period of six months. The present study was conducted to assess the prescription pattern of antibiotic usage. Standard pro-forma was used to collect the information regarding antibiotics, its dose, duration, first line of antibiotics and second line of antibiotics and adverse drug reactions. A Total of 100 ADRs was reported from 100 patients during the study period with female predominance (72%) over males. The average age of the patients in the study was found to be 55-70 years. The majority of the ADRs occurred in the age group of 40-80 years. More number of ADRs was from General Medicine Departments in which the most affected organ systems were the GIT (22%) and the skin (19%). The antibiotic classes mostly accounted were cephalosporin (16%) followed by other. The severity assessment revealed that most of them were moderate followed by mild and severe reactions. Of the reported reactions, 30 % were definitely preventable and causality assessment was done which showed that the reactions were probable, possible. Results show that cephalosporin was extensively used in the department of General medicine. The system should promote the spontaneous reporting of Adverse drug reactions to antibiotics. Proper documentation and periodic reporting to regional Pharmacovigilance centre’s to ensure drug.