A prospective observational study of the clinical presentation and treatment modalities in locally advanced breast carcinoma

Abstract

Breast cancer is the most common site specific cancer in women and is the leading cause of death from cancer for women aged 20 – 59 years. This study aimed at profiling cases of locally advanced breast carcinoma (LABC) with respect to incidence, age at presentation, most common presentation, histologic type and various modalities in management of locally advanced breast carcinoma (LABC). This prospective study followed 45 cases of Locally advanced breast carcinoma over 2 years. It showed almost 100 percent of females presented with palpable lump with other associated complaints. Peak incidence was noted in 4th to 6th decade. Major clinical presentation was lump in breast with most common involvement of upper outer quadrant of either breast. Diagnosis was with fine needle aspiration cytology with common histology of invasive carcinoma no special type (NST) followed by invasive ductal carcinoma. Most common treatment sequence used was Modified radical mastectomy followed by adjuvant chemotherapy followed by adjuvant radiotherapy.